We are Revolutionaries – passionate in our singular pursuit of discovering, developing and delivering innovative, targeted medicines for patients living with cancer. To deliver on our vision, we work relentlessly in pursuit of cutting-edge therapeutic approaches to some of the toughest cancers. Our current focus is on RAS-addicted cancers, which account for 30 percent of all new human cancer diagnoses.

Industry: Biotechnology
Company Size: 201-500 employees

Revolution Medicines

Savvy Admin PROD

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

**The Opportunity:**

Revolution Medicines is seeking a scientifically talented and highly motivated individual to join our Integrated Discovery Research team as Principal Scientist, Head of Analytical Chemistry. In this role, you will drive analytical chemistry strategy and execution within the Medicinal Chemistry function, supporting drug discovery programs from early hit identification through lead optimization and candidate selection. This position offers a unique opportunity to shape analytical science at the frontiers of small molecule beyond Rule-of-Five (bRo5) drug discovery.

Responsibilities:

- Design and lead analytical chemistry strategies and daily operations to support small molecule drug discovery programs across multiple stages.

- Develop and implement robust analytical methods (e.g., LC/MS, HPLC, SFC) for compound characterization, purity assessment (including chiral purity), and stability or reactivity studies (e.g. GSH assay).

- Lead and execute compound purification (including chiral separations), structural elucidation, and physicochemical property assessment in the beyond Rule-of-Five chemical space.

- Collaborate closely with medicinal chemists, process chemists, and DMPK scientists to develop and execute integrated analytical strategies; manage external analytical chemistry service providers to ensure high-quality, timely data delivery.

- Mentor and develop a team of analytical chemists, fostering scientific excellence and professional development.

- Design and implementation of discovery analytics, analytical data integration through collaboration with LabOS team, Data Sciences and Data Analytics functions to develop and implement automated high-throughput analytical methods that enhance efficiency and data quality.

- Ensure compliance with safety standards in laboratory operations.

- Contribute to invention disclosures, patent filings, and external scientific publications as appropriate.

**Required Skills, Experience and Education:**

- Ph.D. in Analytical or Organic Chemistry (or related discipline) with 12+ years of industry experience.

- Demonstrated expertise in advanced analytical method development, troubleshooting, and problem-solving in small molecule drug discovery.

- Strong hands-on experience with chromatographic and spectroscopic techniques, including LC/MS, HPLC, SFC, and NMR.

- Proven experience supporting drug discovery programs across multiple modalities, including small molecules, peptides, and antibody–drug conjugates (ADCs).

- Strong problem-solving skills with sound technically driven decision-making ability.

- Excellent communication skills and the ability to drive cross-disciplinary partnerships.

- A track record of innovation and execution in fast-paced, data-driven research environments.

**Preferred Skills:**

- Experience supporting beyond Rule-of-Five (bRo5) medicinal chemistry, including macrocycles, covalent inhibitors, or other alternative modalities.

- Ability to integrate analytical insights into medicinal chemistry decision-making.

- Working knowledge of lab automation and high-throughput analytical techniques.

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

Base Pay Salary Range

$190,000 - $238,000 USD

~~We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.~~

~~Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official **@revmed.com ** email address.~~

~~If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to **careers@revmed.com ** so we can share these impersonations with our IT team for tracking and awareness.~~

Principal Scientist, Analytical Chemistry

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

**The Opportunity:**

We are seeking a Principal Machine Learning Scientist to lead the development of advanced machine learning approaches that accelerate small-molecule drug discovery. This role sits at the intersection of data science, chemistry, and biology, transforming complex scientific datasets into predictive models that guide target discovery, compound design, and translational hypotheses.

Working closely with experimental scientists, the Principal ML Scientist will develop cutting-edge modeling approaches that integrate chemical, biological, and phenotypic data. The successful candidate will play a key role in advancing a data-driven discovery strategy by designing predictive models, deploying innovative algorithms, and translating insights into actionable decisions that improve the speed and success of the discovery of medicines for patients with RAS-driven cancers.

Key responsibilities include:

Scientific Leadership:

- Define and lead machine learning strategies that accelerate early-stage drug discovery.

- Identify opportunities where AI and advanced analytics can meaningfully improve scientific decision-making.

- Drive the adoption of innovative modeling approaches within multidisciplinary discovery teams.

Model Development:

- Develop predictive models for:

- Compound activity, selectivity, ADME/Tox, and developability properties.

- Target engagement, mechanism-of-action, and phenotypic datasets.

Apply modern ML techniques such as:

- Graph neural networks.

- Deep learning for molecular representation.

- Generative chemistry models.

- Active learning frameworks for experimental design.

Cross-Functional Collaboration:

- Partner with medicinal chemists to guide compound design and optimization.

- Work with biologists to interpret complex experimental datasets and generate mechanistic hypotheses.

- Collaborate with data scientists and engineers and ML engineers to deploy models into scalable discovery workflows.

Data Integration:

- Integrate heterogeneous datasets including:

- Chemical structure and screening data.

- Imaging and phenotypic screening data.

- Structural biology and molecular simulation outputs.

**Required Skills, Experience and Education: **

- PhD in machine learning, computational chemistry, computational biology, computer science, or a related quantitative discipline.

- 8+ years experience applying machine learning or advanced analytics to scientific problems.

- Demonstrated experience working with chemical or biological datasets in drug discovery or related domains.

- Strong expertise in:

- Python-based ML ecosystems (PyTorch, TensorFlow, scikit-learn).

- Data analysis and scientific computing (NumPy, Pandas).

- Deep learning and representation learning techniques.

- Strong understanding of early-stage drug discovery workflows.

- Ability to translate biological or chemical questions into computational frameworks and predictive models.

- Proven ability to communicate complex computational insights to.

- Passion for scientific innovation and a relentless commitment to improving patient outcomes.

**Preferred Skills:**

- Proven track record of applying advanced AI/ML approaches (deep learning, generative modeling, structure-based ML) to drug discovery or related life sciences domains.

- Experience with cheminformatics or bioinformatics toolkits is highly desirable.

- Familiarity with cloud computing and scalable ML workflows is a plus

- Ability to work at the interface of computational and experimental science.

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

Base Pay Salary Range

$273,000 - $321,000 USD

~~We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.~~

~~Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official **@revmed.com ** email address.~~

~~If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to **careers@revmed.com ** so we can share these impersonations with our IT team for tracking and awareness.~~

Principal Machine Learning Scientist, Drug Discovery Analytics

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

**The Opportunity:**

Playing a critical role as a lead statistician for clinical Late-Stage program(s) and the subject matter expert (SME) in Biostatistics within Quantitative Sciences function, this position is to serve as a program level lead statistician and provide statistical leadership and support for clinical development strategy and programs through product life cycle.

- Lead strategic, statistical thinking and contributions to clinical development plans.

- Represent Biostatistics function on cross-function teams at program level and serve as a lead statistician for oncology studies.

- Collaborate with various functions on study design and planning, protocol development, statistical analysis plan and analysis specifications.

- Provide statistical support for study protocol development, analysis plan and specification through direct involvement and/or providing guidance to junior staff.

- Plan and prepare independent data monitoring committee (DMC), coordinate with independent statistical data analysis center for DMC and study team for periodic DMC reviews.

- Collaborate with data management and clinical operations over the course of clinical studies to provide statistical input to study conducts and database development as well as data collection and cleaning activities.

- Collaborate with statistical programming to ensure that appropriate programs and documentations are being developed for datasets development and outputs generation, and ensure the statistical analyses specified in scientific protocols and/or analysis plans are conducted appropriately.

- Provide statistical input and leadership to the development of global health authority documents, regulatory interaction and response to health authority submissions.

- Provide statistical support for clinical publications, assist in data interpretation to ensure consistency and accuracy in data presentation.

- Drive and lead department initiatives, best practices, and guidelines.

- Keep abreast in new developments in statistics, drug development, and regulatory guidance and share knowledge with functional and cross-functional team members.

**Required Skills, Experience and Education:**

- Ph.D. or M.S. in Statistics/Biostatistics, minimum 10 years (for Ph.D.) and 14 years (for M.S.) of experience in biotech/pharma industry as a statistician. Level will be determined based on the relevance of experience.

- Extensive experience in design and conduct of phase 3 oncology trials.

- Solid knowledge in ICH and other regulatory requirements related to biostatistical activities and clinical trials.

- Excellent verbal and written communication skills are required.

- Good interpersonal and project management skills are essential.

- Proficiency in SAS and/or R.

**Preferred Skills:**

- Experience with lead role in NDA/BLA filing desirable.

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

Base Pay Salary Range

$244,000 - $305,000 USD

~~We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.~~

~~Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official **@revmed.com ** email address.~~

~~If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to **careers@revmed.com ** so we can share these impersonations with our IT team for tracking and awareness.~~

Senior Director, Biostatistics – Late Phase

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

**The Opportunity:**

We are seeking an experienced oncology drug-development leader to serve as Global Development Lead (GDL) for one of Revolution Medicines’ most advanced clinical programs. This is a senior, program-accountable leadership role with end-to-end ownership of clinical development strategy and execution for a late-stage asset, including pivotal studies, regulatory engagement, and long-range planning.

The GDL functions as the single point of clinical accountability for the assigned program, setting direction, driving alignment across functions, and representing the program at internal governance bodies and externally with investigators, key opinion leaders, and global health authorities. This position sits at the Executive Director level within Clinical Development and carries program-level accountability and authority typically associated with the most senior clinical leaders in the organization.

In addition to program ownership, the GDL serves as a senior clinical advisor to development leadership, contributing perspective to cross-program and enterprise-level development discussions as appropriate.

**Responsibilities**

Program & Clinical Strategy

- Own and lead the global clinical development strategy for the assigned program, integrating scientific, clinical, regulatory, biomarker, and commercial considerations.

- Partner closely with the Project Team Leader (PTL) or Lifecycle Team Leader (LCL) to ensure that clinical development strategy, positions and decision-making are fully represented and integrated within lifecycle planning and decision-making for the molecule, with clear alignment on roles, decision rights and accountability.

- Develop and maintain the Target Product Profile (TPP), Clinical Development Plan (CDP), risk assessments, scenario analyses, and long-range program roadmap.

- Present strategic recommendations to internal governance bodies (e.g., DRG, SMT, PRG, ePRG) and drive high-quality, timely program decision-making.

- Ensure strategy reflects deep disease-area insight, emerging science, competitive intelligence, and evolving regulatory expectations.

Execution & Oversight

- Accountable for the design, execution, and delivery of pivotal and registration-enabling studies (Phase 2/3), including protocol strategy, enrollment and geographic planning, patient safety oversight, and data interpretation.

- Ensure alignment and harmonization across related studies within the program and across regions to support coherent regulatory and lifecycle objectives.

- Provide senior clinical leadership across functions to anticipate risk, resolve complex issues, and ensure delivery of critical milestones, leveraging matrixed teams rather than direct operational control.

- Guide preparation of regulatory briefing materials and serve as the senior clinical representative in global health authority interactions.

Scientific & Medical Leadership

- Serve as the program’s senior medical authority, providing deep expertise in pancreatic and colorectal cancers.

- Translate scientific, translational, and biomarker insights into actionable clinical strategy.

- Engage key opinion leaders, investigators, advisory boards, and external experts to refine development strategy and strengthen scientific and clinical positioning.

Cross-Functional & Enterprise Leadership

- Serve as the clinical and strategic leader for the assigned program, with clear accountability for clinical direction and integrated decision-making across functions.

- Lead a high-performing, cross-functional Global Development Team, in close partnership with the PTL or LCL, ensuring clarity of direction, strong collaboration, and accountability for outcomes.

- Demonstrate the ability to lead through both influence and authority in situations where program priorities cut across functions, senior leaders, and organizational boundaries.

- Partner with Medical Affairs and Commercial colleagues to ensure alignment between clinical strategy and future market needs.

- Act as a visible senior leader within Clinical Development, modeling enterprise mindset and contributing to broader discussions on development strategy, standards, and best practices beyond the assigned program.

People Leadership & Organizational Impact

- Assume leadership of an established, multidisciplinary Clinical Development Team, including multiple senior direct reports, with immediate accountability for alignment, performance, and delivery across the program.

- Rapidly assess team capabilities, clarify roles and decision rights, and establish operating cadence to ensure seamless execution during critical late-stage development phases.

- Demonstrated ability to step into complex, high-visibility leadership situations and effectively lead teams through transition, inflection points, or accelerated timelines.

- Mentor senior clinical development staff and contribute to capability-building across the broader organization.

- Model Revolution Medicines’ values of scientific rigor, transparency, inclusiveness, and commitment to patients.

- Contribute to the evolution of development processes, tools, and governance practices that enhance efficiency, quality, and scalability across the portfolio.

**Required Skills, Experience & Education:**

**Medical & Scientific Qualifications**

- MD (or international equivalent) with board certification in Medical Oncology or Hematology/Oncology; adult solid tumor focus strongly preferred.

- Recognized expertise in NSCLC developed through academic clinical leadership and/or substantial industry experience.

Clinical Development Leadership

- Depth of experience typically gained at least 13 years in oncology clinical development, or a combination of senior academic clinical leadership and relevant industry roles.

- (Academic leadership may be counted when directly related to oncology trials and patient care.)

- Demonstrated leadership of global, late-stage development programs, including design and execution of pivotal Phase 2/3 studies.

- Experience owning or leading global regulatory strategy, including direct involvement in multiple interactions with global health authorities.

- Experience contributing to or leading regulatory submissions (NDA/BLA/MAA); multiple submissions strongly preferred.

Enterprise Leadership & Influence

- Proven ability to align and influence senior stakeholders across a highly matrixed organization.

- Exceptional ability to communicate complex scientific and clinical concepts clearly to executives, cross-functional partners, and external experts.

- Demonstrated skill in navigating conflict, establishing role clarity, and building durable cross-functional trust.

- Demonstrated commitment to developing people and building strong, resilient teams.

**Other**

- Excellent written and verbal communication skills.

- Ability to travel approximately 25–30% (domestic and international).

- San Francisco Bay Area preferred, but hybrid acceptable.

**Preferred Skills:**

- Prior academic appointment in medical oncology with leadership of clinical trials.

- Experience integrating translational and biomarker strategies into late-stage clinical development.

- Publication record supporting disease-area credibility.

- Experience supporting commercialization planning or launch readiness.

- Exposure to cross-program or portfolio-level development strategy and governance.

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

Base Pay Salary Range

$369,000 - $424,000 USD

~~We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.~~

~~Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official **@revmed.com ** email address.~~

~~If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to **careers@revmed.com ** so we can share these impersonations with our IT team for tracking and awareness.~~

Global Development Lead (GDL), Clinical Development – Lung Cancer

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

**The Opportunity:**

Reporting to the VP, Global Commercial Development Disease Area Lead, this newly created role will serve as a leader for continuing to build our global oncology marketing capabilities driving global commercial strategy at product team and overseeing global launch strategy and lifecycle planning for a given indication/indications. Candidates should be passionate about leading cross-functional collaboration, and contributing as both a strategic leader and hands-on driver in a growing organization. This position is primarily remote with travel required for scientific and team meetings.

Specifically, you will be responsible for:

- Partner across the company including with clinical development, medical affairs, market access, to drive indication strategy, shape brand strategies across the product team.

- Ensure global readiness to drive successful launch planning, commercialization, and performance tracking across the U.S. and key ex-U.S. markets.

- Execute global disease area strategy, brand strategies, including branding, positioning, messaging, and value propositions that guide regional affiliates and align with long-term portfolio goals.

- Translate scientific and market insights into compelling strategies, launch narratives, and execution plans; effectively communicating recommendations and leading strategic discussions with global and regional stakeholders.

- Develop and refine global brand plans, including revenue and patient forecasts, to inform investment decisions, lifecycle strategies, and portfolio prioritization.

- Drive excellence in global launch execution: creating launch frameworks, ensuring best practices are shared across affiliates, and monitoring progress to anticipate and resolve challenges.

- Identify and manage external agencies, vendors, and partners to deliver impactful global campaigns, educational initiatives, and engagement platforms.

- Serve as a trusted resource to executive leadership in identifying opportunities to maximize commercial value, expand indications, and differentiate in competitive markets.

- Bring innovation and new capabilities to global marketing—collaborate with IS Commercial to integrate digital, omnichannel, and data-driven approaches to build a best-in-class commercial function.

- Up to 50% of travel required.

**Required Skills, Experience and Education:**

- Bachelor’s degree required (MBA preferred) with at least 15+ years of progressive commercial experience in a biotechnology and/or pharmaceutical company including strategic marketing and ideally sales.

- Proven success of developing and executing global marketing strategy.

- Experience in leading the global launch of new product in competitive spaces.

- Demonstrated ability to derive insights/analytics leading to the development of innovative marketing strategies.

- Strong leadership, with the ability to lead teams, work well cross-functionally, and influence across the organization to create a clear sense of direction.

- Excellent organizational skills and an ability to prioritize effectively to deliver results within reasonably established timelines.

- Ability to represent Revolution Medicines well externally: strong interpersonal skills including verbal and written communication.

- Entrepreneurial mindset, with a tolerance for ambiguity, and a passion for helping cancer patients.

**Preferred Skills:**

- Experience with an oncology launch is desired.

- Prior experience in a smaller, rapidly growing, company.

- Experience in gastrointestinal or lung cancer preferred.

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

Base Pay Salary Range

$265,000 - $331,000 USD

~~We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.~~

~~Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official **@revmed.com ** email address.~~

~~If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to **careers@revmed.com ** so we can share these impersonations with our IT team for tracking and awareness.~~

Executive Director, Global Commercial Lead

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

**The Opportunity:**

Reporting directly to the Executive Director, Global Analytics and Insights, the Competitive Intelligence role requires strategic thinking and expertise to provide critical contributions to brand strategy, launch and life-cycle planning, forecasting, and product and portfolio decisions. This role involves providing comprehensive strategic and competitive insights to support decision-making and strategy-setting across various development programs. The ideal candidate will play a crucial role in monitoring and evaluating the competitive landscape, conducting comprehensive threat assessments, and collaborating with key stakeholders to inform strategic planning. This position would ideally be based at our headquarters in Redwood City, CA., however open to remote candidates who are willing to travel to our CA office on a regular basis.

Responsibilities Include:

- Conducts thorough competitive and market assessments to identify market dynamics, trends, and potential impacts on Revolution Medicines’ pipeline, delivering insights to key stakeholders.

- Collaborates with stakeholders across the company (including Commercial, Medical Affairs, and R&D) to integrate internal and external information, analytics, and data.

- Coordinates and execute coverage of key medical congresses; outputs may include daily and post-conference summaries and post-conference summary presentations.

- Maintains an in-depth understanding of Revolution Medicines’ diverse product offerings, competitive positioning, and the broader market dynamics shaping the industry's future.

- Benchmarks competitor clinical data, business models and capabilities.

- Translates insights into strategic recommendations to inform and influence decision making and strategy setting.

- Proactively facilitates the identification and prioritization of intelligence efforts critical to strategic planning and execution for key stakeholders; provides direction for the design and refinement of intelligence plans.

- Reinforces Competitive Intelligence best practices, identifies secondary data sources, vendor options, and methodologies that are best suited to address a business need. Manages third parties associated with this function.

- Participates in cross-functional teams to gather input for functional activities and to ensure alignment.

- Consistently and effectively communicates with key stakeholders in a timely manner to inform on critical updates.

**Required Skills, Experience and Education:**

- Minimum of 8 years experience in competitive intelligence, market research, or a related field within the pharmaceutical and/or biotechnology industry.

- Demonstrated leadership, influencing skills, creativity, problem solving and ability to manage complexity.

- Experience in new product launches and pre-launch environments.

- Track record of being a collaborative team player, and adaptive to meet the needs of a growing business.

- Excellent organizational skills and an ability to prioritize effectively to deliver results within reasonably established timelines.

- Ability to represent Revolution Medicines well: strong interpersonal skills including verbal and written communication.

- Entrepreneurial mindset, with a tolerance for ambiguity, and a passion for helping cancer patients.

**Preferred Skills:**

- Advanced degree (PhD, Master’s) preferred.

- 10+ years of experience in competitive intelligence with focus in Oncology.

- Demonstrated ability to synthesize complex information and influence decision-making at the executive level.

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

Base Pay Salary Range

$201,000 - $251,000 USD

~~We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.~~

~~Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official **@revmed.com ** email address.~~

~~If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to **careers@revmed.com ** so we can share these impersonations with our IT team for tracking and awareness.~~

Director, Global Competitive Intelligence

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

**The Opportunity:**

Reporting directly to the Senior Director, Global Insights, the Director, Global Insights role requires strategic thinking and expertise to provide critical contributions to disease area strategy, life-cycle planning and product and portfolio decisions. The individual in this role will be responsible for conducting market research in a variety of geographies to help support the development and potential commercialization of the RevMed portfolio and will be an influential voice in developing asset strategy. The ideal candidate will have experience working on pipeline molecules in Oncology across multiple geographies, strong problem-solving skills, a strategic mindset, and will exhibit curiosity, flexibility, and be comfortable with ambiguity.

This position would ideally be based at our headquarters in Redwood City, CA., however open to remote candidates who are willing to travel to our CA office on a regular basis.

Responsibilities include:

- Works cross functionally to develop and execute the global insights roadmap in support of current business needs and future opportunities across the portfolio of targeted oncology molecules.

- Translates insights into strategic recommendations to inform and influence global business decision making.

- Communicates strategic insights from market research to drive critical business decisions and strategy.

- Initiates and facilitates activities that enhance organizational knowledge regarding the relevant market and potential product attributes, usage, market dynamics, and competition.

- Communicates and aligns key internal stakeholders around market research and analytics objectives and outputs including qualifying the results based on the strength of the data and identifying limitations.

- Develops and presents actionable recommendations to key stakeholders, focusing on key findings and relevant implications to each stakeholder group, and senior leadership.

- Researches, analyzes, and formulates insights on complex markets, various disease states, competitive landscapes, and relevant market and managed care dynamics.

- Synthesizes and communicates the similarities, differences, and considerations necessary to inform Global clinical development plans.

- Participates in cross-functional teams to gather input for functional activities and ensures alignment.

- Partners closely with other Insights and Analytics functions at the Global and Regional level (Market Research, Data Analytics, Competitive Intelligence).

- Works closely with Global Commercial Development, Clinical Development, Portfolio Management, and Medical Affairs to support early-stage decision making.

- Maintains an in-depth understanding of Revolution Medicines’ diverse product offerings, competitive positioning, and the broader market dynamics shaping the industry's future.

- Reinforces market research best practices, identify market research and data sources, vendor options, and methodologies that are best suited to address a business need. Manages third parties associated with this function.

- Serves as a resource to identify and tracking key business drivers.

**Required Skills, Experience and Education:**

- Bachelor's degree required (MBA preferred) with 10+ years of progressive experience in a pharmaceutical, biotechnology, or strategic consulting role with 6+ years of experience in a strategic analytics role.

- Experience supporting pipeline and portfolio decision making.

- Extensive primary research and secondary analytical skills required; ability to translate the data and learning into actionable recommendations for business growth.

- Experience conducting and coordinating of market research in regions outside the U.S.

- Track record of being a collaborative team player, and adaptive to meet the needs of a growing business.

- Strong problem solver with experience leveraging a variety of research and analytical vendors, study designs, and building quality research vendor partnerships.

- Demonstrated ability to influence senior management and key business partners.

- Excellent organizational skills and an ability to prioritize effectively to deliver results within reasonably established timelines.

- Ability to represent Revolution Medicines well with internal and external stakeholders, including strong interpersonal skills including verbal and written communication.

- Entrepreneurial mindset, with a tolerance for ambiguity, and a passion for helping cancer patients.

**Preferred Skills:**

- Experience with targeted oncolytics.

- Demonstrated ability to synthesize complex information and influence decision-making at the executive level.

- Proven experience in a smaller, rapidly growing, company.

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

Base Pay Salary Range

$211,000 - $264,000 USD

~~We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.~~

~~Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official **@revmed.com ** email address.~~

~~If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to **careers@revmed.com ** so we can share these impersonations with our IT team for tracking and awareness.~~

Director, Global Insights

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

**The Opportunity:**

We are seeking a Senior Machine Learning Scientist to help accelerate drug discovery through advanced analytics and artificial intelligence. This role will develop predictive models and analytical methods that transform complex biological and chemical datasets into actionable insights that guide research decisions.

The Senior Machine Learning Scientist will work at the interface of data science, chemistry, and biology to support target discovery, compound optimization, and translational research. This position requires both strong machine learning expertise and the ability to collaborate effectively with experimental scientists to solve real-world scientific problems.

The successful candidate will contribute to building a data-driven discovery ecosystem where data, analytics, and experimentation continuously inform and accelerate one another.

Key responsibilities include:

Develop Predictive Models for Drug Discovery

- Design and implement machine learning models to predict compound activity, selectivity, and developability.

- Develop predictive frameworks for ADME/Tox, target engagement, and phenotypic screening outcomes.

- Apply advanced modeling approaches including deep learning, graph neural networks, and ensemble methods.

- Evaluate model performance and apply appropriate validation strategies.

- Work with data engineers and ML engineers to integrate models into discovery pipelines.

Analyze Complex Scientific Data

- Perform exploratory data analysis on chemical, biological, and phenotypic datasets.

- Integrate heterogeneous datasets including:

- Chemical structure and screening data.

- High-content imaging data.

- Structural biology and molecular simulation outputs.

- Identify patterns and relationships that inform scientific hypotheses.

Collaborate with Research Scientists

- Partner with medicinal chemists to support compound design and lead optimization.

- Work with biologists to interpret experimental results and identify new target opportunities.

- Translate scientific questions into computational modeling strategies.

**Required Skills, Experience and Education:**

- PhD in machine learning, computational biology, computational chemistry, computer science, statistics, or a related quantitative field.

- 4–8 years experience applying machine learning or advanced analytics to scientific datasets.

- Python and scientific computing libraries (NumPy, Pandas, SciPy).

- Machine learning frameworks (PyTorch, TensorFlow, scikit-learn).

- Model development, validation, and evaluation methods.

- Data visualization and exploratory analysis.

- Experience working with noisy and incomplete experimental datasets.

**Preferred Skills:**

- Cheminformatics or molecular modeling tools (RDKit, OpenEye, etc.).

- Multi-omics data analysis.

- Cloud computing environments.

- MLOps or scalable model deployment.

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

Base Pay Salary Range

$229,000 - $269,000 USD

~~We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.~~

~~Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official **@revmed.com ** email address.~~

~~If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to **careers@revmed.com ** so we can share these impersonations with our IT team for tracking and awareness.~~

Senior Machine Learning Scientist, Drug Discovery Analytics

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

**The Opportunity:**

We are seeking a highly motivated individual eager to develop their program management skills. This position reports to the Business Operation Team, which is part of the Program Management Group.

As a Project Coordinator, you will work closely with various members of the Business Operation team and cross-functional leaders to support departmental and project goals. You are able to “roll up your sleeves” and thrive in a fast-paced, highly cross-functional environment. You have a desire to streamline and organize project work and build dashboard and report that enables decision making. You enjoy working in a collaborative setting and strive to bring out the best of your teammates.

Activities as part of your typical day may include:

- Working with project managers to create integrated project plans with established goals, milestones, and timelines. In doing so, you will develop and expand your competencies with program management processes and tools.

- In working with program teams, you will gain depth of understanding drug development processes and the approaches critical to effectively advance programs to key milestones.

- Building interpersonal skills to enhance your ability to positively influence the performance of the teams your support.

- Fostering an open, inclusive, and collaborative culture with a focus on shared learnings within the Program Management group.

**Required Skils, Experience and Education:**

- B.A. or BSc. in Life Sciences with 2-3 years’ experience in a scientific or similarly related field.

- Demonstrated willingness to live by the RVMD Core Values and excitement about our mission.

- Excellent verbal and written communication skills.

- Strong interest in learning and developing professional skills.

- Quick study, able to grasp concepts and apply to related areas.

- Highly organized, have strong interpersonal skills, and is detailed oriented.

- Ability to prioritize key scientific questions and relevant studies to address those within multiple programs.

- Ability to multi-task across multiple projects.

- Leverages discretion to determine probability of likely success and meaningfulness of data.

- Contributes to building a positive team spirit, shares expertise with others.

- Exhibits impeccable integrity and sound judgment with sensitive information.

- Able to adapt to changes in the work environment.

- Possess the ability to quickly assess problems/situations, provide effective resolution/solutions and raise and manage risks and discrepancies where needed using scientific knowledge.

- Proficient with Microsoft Suite (Word, PowerPoint, Excel, Outlook), Power BI Smartsheet, MS Project, Timeline Office Pro, a plus.

**Preferred Skills:**

- MSc., MBA or Ph.D. in a scientific or similarly related field a plus

- PMP (Project Management Professional) or other PM certification or equivalent is a plus.

- Experience in Oncology therapeutic area is strongly preferrable.

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

Base Pay Salary Range

$90,000 - $108,000 USD

~~We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.~~

~~Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official **@revmed.com ** email address.~~

~~If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to **careers@revmed.com ** so we can share these impersonations with our IT team for tracking and awareness.~~

Project Coordinator

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

**The Opportunity:**

We are looking for motivated structural biologist to join tour team to support multiple oncology therapeutic programs. The ideal candidate will have previous, hands-on experience in sample preparation, data acquisition and data analysis from both X-ray crystallography and cryo-EM. They will apply their expertise to form compound driven complexes, identify, and optimize crystallization/CryoEM conditions with the aim of determining high resolution structural information to drive small molecule design and mechanistic understanding. We’re seeking a team player with enthusiasm to work in an interdisciplinary setting to drive toward new, cutting edge oncology therapeutics.

**Responsibilities**

- Plan and execute experiments with the aim of determining small molecule driven multi-protein complex structures by CryoEM and X-ray crystallography.

- Perform cryo-EM grid screening, optimization, data collection and refinement to enable high-quality structure determination.

- Interact with interdisciplinary teams (including chemists, computational chemists, biologists, project teams, and management) and clearly articulate structural data in a broader drug discovery context.

- Maintain excellent records and communication among internal and external colleagues.

- Be driven by a desire to be innovative in a high energy, fast paced environment and work collaboratively with a variety of collegues across the organization.

**Required Skills, Experience and Education:**

- PhD in structural biology or protein biochemistry or a related scientific discipline with 2-5 years of post-doctoral experience.

- Hands-on experience and expertise in cryo-EM sample optimization and grid preparation, data collection, map generation, and structure determination.

- Strong track record of solving challenging CryoEM problems such as preferred orientation, small proteins/complexes, modeling into low resolution maps, or iterative rounds of protein optimization.

- Hands on experise with modern software packages for data collection, refinement and visualization of structural biology data, and the ability to seamless switch between them based on need (e.g. CryoSPARC, RELION, Phenix, REFMAC, Coot, ChimeraX, Pymol).

- Excellent written, verbal communication, interpersonal and organization skills.

- Conscientious team-player interested in a fast-paced biotech environment.

**Preferred Skills:**

- Hands-on experience and expertise in protein crystallization, crystal optimization and harvesting for data collection.

- Experience with biophysical characterization methods, including mass spectrometry, SEC-MALS, DLS, SPR, NMR and thermal shift assays.

- Experience with protein-protein complexes including antibodies/Fabs, molecular glues, PROTACs, etc.

- Experience working in a multidisciplinary team environment.

- Experience in gene construct design, expression and purification of recombinant proteins.

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

Base Pay Salary Range

$132,000 - $166,000 USD

~~We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.~~

~~Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official **@revmed.com ** email address.~~

~~If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to **careers@revmed.com ** so we can share these impersonations with our IT team for tracking and awareness.~~

Scientist II, Structural Biology

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