We sequence proteins. Glyphic Biotechnologies is a biotechnology startup revolutionizing the field of proteomics. While DNA can reveal biological insights, proteins actually tell us what our bodies will do. We are developing a first-of-its-kind, next-generation protein sequencing platform to enable researchers to gain novel insights into biology and disease.

Industry: Biotechnology Research
Company Size: 11-50 employees

Glyphic Biotechnologies

Savvy Admin PROD

**About Glyphic:**

At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$80M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.

**What we are looking for in you**

We are seeking a technically driven, detail-oriented, and collaborative Scientist to support sample preparation method development. Reporting to the Director of Assay Development you will test and optimize Glyphic's single-molecule protein sequencing platform, ensuring it achieves industry-leading metrics for robustness, sensitivity, and scalability. A critical component of this work involves developing and integrating specialized sample preparation protocols for diverse biological inputs with stringent downstream requirements for high-purity and high-accuracy proteomic applications. Your work will directly advance the development of a high-throughput, end-to-end sequencing solution built for real-world samples.

The ideal candidate independently troubleshoots complex technical challenges, rapidly iterates on experimental designs, and communicates effectively across multidisciplinary teams. A track record of adapting protocols for novel sample types and executing within high-throughput environments will be key to making an immediate impact.

This is a full-time, exempt, in-person position with work conducted at our Berkeley, CA location.

**What you'll do**

Assay Development

- Design, test, and optimize inputs for ProSE experiments for robustness, sensitivity, and scalability, including improving reaction efficiency and accuracy.

- Lead the integration of novel chemistry developments into sample preparation and assay workflows, driving high-precision proteomic peptide generation with an eye toward reproducibility, automation, and scalability.

- Optimize and integrate C-terminal and side-chain blocking chemistries - developed by the Chemistry team - into automated assay workflows.

- Propose and qualify in-process controls and analytical tools to build a comprehensive understanding of the factors driving sequencing efficiency across peptides with diverse physicochemical properties, including length, hydrophobicity, and charge.

- Apply chemoenzymatic synthesis approaches and characterize individual enzymatic reaction steps to evaluate efficiency, selectivity, and compatibility.

Sample Preparation:

- Introduce and validate real biological sample inputs, enabling sequencing of diverse, relevant material across a range of sample types and complexities.

- Evaluate and process incoming Key Opinion Leader (KOL) samples, ensuring preparation methods accommodate sample-specific constraints and analytical requirements.

- Assess diverse sample types, determine appropriate analytical approaches, and develop extraction and purification protocols for inputs derived from matrices such as cells, tissues and blood, collaborating with chemists to scale and integrate these methods into high-throughput workflows.

- Develop and implement strategies for sample enrichment, depletion, and dynamic range management to optimize ProSE sequencing yield.

- Support the generation and sourcing of standard reference materials using cell culture techniques, including establishing the instrumentation needed to produce and purify proteins and peptides from cell cultures and other biological materials.

**What you need**

Required:

- Degree in biochemistry, chemical biology, molecular biology, or an equivalent field; including:

- PhD / MS / BS with 4+ / 6+ / 8+ years of relevant experience (Senior Scientist)

- PhD / MS / BS with 0+ / 2+ / 4+ years of relevant experience (Scientist I)

- Demonstrated expertise in developing and optimizing ultrasensitive proteomic assays from real biological samples, with experience generating quantitative readouts across diverse analytical platforms (e.g., LCMS for discovery proteomics).

- Experience processing real biological samples from various sources (cell lines, blood, tissue, etc.)

- Expertise with developing sample preparation or enrichment methods for low-abundance targets or limited input material.

- Understanding of peptide chemistry and strategies to prevent degradation of post-translational modifications (PTMs), such as methylation and phosphorylation.

- Excellent problem-solving skills and strong attention to detail.

- Excellent written and verbal communication skills, with the ability to collaborate effectively across diverse scientific and technical backgrounds.

- Ability to thrive in a fast-paced environment with evolving priorities.

Nice to have:

- Deep familiarity with highly multiplexed, high-sensitivity protein quantification platforms (e.g., nELISA, NuLISA, immunoassays, PLE, or PEA).

- Experience with nanopore platforms for sequencing or label-free detection.

- Experience with single-cell or spatial proteomics and transcriptomics.

- Comfort working with R or Python to input experimental results and navigate established data analysis workflows.

We're looking for a teammate that:

- Navigates complex team dynamics, partnerships, and challenges with creativity and logic.

- Operates with adaptability, urgency, and flexibility in evolving environments, thriving in ambiguity.

- Drives work forward without needing to be asked, taking responsibility for outcomes rather than tasks.

- Treats obstacles as problems to be creatively solved, not reasons something can't be done.

- Applies sound judgment to the best available information, testing, learning, and iterating.

- Shares early and directly when assumptions change, results are unclear, or timelines are at risk.

**What you can expect from this role**

Work environment:

- Collaborative culture where your ideas and expertise are valued

- Direct impact on product development and company direction

Professional growth:

- Learn from a diverse team of world-class scientists and engineers

- Contribute to first-of-their kind technologies, high-impact publications, and patents

- Opportunity to develop and manage relationships with Key Opinion Leaders

**Compensation**

Estimated Base Salary $90,200 - $161,950

This is the pay range for this position that we reasonably expect to pay. Individual compensation is based on various factors including, experience, education, skillset, and geographic location. This range is for the SF Bay Area, California location and may be adjusted to the labor market in other geographic areas.

Benefits and Perks:

- Employee Stock Option Plan

- 100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)

- Employer Retirement Contributions to 401(k)

- Generous Paid Time Off

- Paid Maternity and Paternity Leave

- Health & Wellbeing Program

- Office Snacks and Beverages

- Regular Team Bonding Activities

We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Individuals seeking employment at Glyphic Biotechnologies are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.

Scientist / Senior Scientist, Assay Development (Sample Prep)

**About Glyphic:**

At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$80M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.

**What we are looking for in you**

Glyphic is seeking a Scientist or Senior Scientist to build and sustain the reagent supply infrastructure that powers our single-molecule proteome sequencing platform. In this role you will own the full reagent lifecycle — from early formulation and characterization through stability qualification, QC method development, and lot release — ensuring that every critical material entering a multi-cycle expansion run meets Glyphic's performance standards.

The ideal candidate brings deep hands-on expertise in biochemical reagent development with a quality-by-design mindset: methodical in experimental approach, rigorous in documentation, and proactive in building the frameworks that sustain consistency at scale. You have experience not just characterizing reagents but qualifying them — setting acceptance criteria, gating go/no-go decisions on incoming lots, and maintaining the provenance records that high-stakes single-molecule runs demand. You are comfortable working at the bench and translating your findings into SOPs, QC protocols, and reagent inventories that the broader Assay Development team can rely on.

This is a full-time, exempt, in-person position with work conducted at our Berkeley, CA location.

**What you'll do**

Reagent Development & Formulation

- Lead assay reagent development activities, including formulation, characterization, and optimization, for components used in ProSE single-molecule expansion and library preparation workflows, including enzymes, oligos, beads, and solvents.

- The materials in scope extend beyond standard biological reagents to include chemically reactive compounds and environmentally sensitive materials susceptible to degradation by oxygen, humidity, light, and temperature fluctuations. Working with these materials demands a chemistry-aware approach to formulation, handling, and storage.

- Characterize reagent performance using design-of-experiments (DOE) approaches, systematically varying formulation conditions, buffer composition, excipients, and process parameters to establish operating bounds and define product specifications.

- Design and execute experiments to evaluate reagent performance in end-use assay configurations; develop a mechanistic understanding of how reagent composition, lot variability, and environmental sensitivity impact expansion assay outcomes.

- Design and execute reagent storage stability studies under accelerated and real-time conditions; develop stability-indicating assays; interpret results against established product specifications and flag out-of-spec trends proactively.

QC Framework & Lot Qualification

- Build and implement a QC and control framework for platform reagents, including acceptance criteria, lot release protocols, and QC assay development, to support reliable, consistent supply to the Assay team.

- Develop, qualify, and transfer QC test methods for reagent characterization and lot release, including HPLC, fluorescence-based functional assays, and physical characterization methods; set product, process, and incoming material acceptance criteria in collaboration with Assay and cross-functional partners.

- Qualify each reagent lot prior to use in multi-cycle or KOL runs; execute hands-on QC testing encompassing physical, chemical, and functional characterization; gate go/no-go decisions on input materials and maintain provenance records for high-stakes runs.

- Maintain batch records and quality documentation in accordance with internal standards.

SOPs, Inventory & Continuous Improvement

- Establish and maintain SOPs for assay reagents and integrated workflows; systematically investigate lot-to-lot variability and failure modes; troubleshoot deviations and lead root cause analysis and corrective action.

- Guard-band critical reagent components and workflow steps to establish the operating bounds of new protocols and define tolerance limits for expansion assay parameters.

- Forecast and maintain end-to-end reagent inventory for SOP-level runs, ensuring the Assay team has qualified materials available on schedule for integration runs and platform demonstrations.

- Partner with the Automation team to implement and qualify reagent-dependent assay steps on work cell or Hamilton-based platforms; qualify liquid-handling methods against reagent specifications.

- Analyze experimental data using statistical methods; synthesize results to identify trends and trace them to upstream reagent, process, or formulation variables; communicate findings through technical reports and presentations, and maintain comprehensive documentation to ensure reproducibility and preserve institutional knowledge.

**What you need**

Required:

- Degree in Biochemistry, Chemical Biology, Biophysics, Biomedical Engineering, or an equivalent field; industry experience including:

- PhD / MS / BS with 4+ / 6+ / 8+ years of relevant experience (Senior Scientist)

- PhD / MS / BS with 2+ / 4+ / 6+ years of relevant experience (Scientist II)

- Proven bench expertise in reagent development or analytical science, with hands-on experience across biochemical characterization techniques with the ability to establish operating bounds and guard bands for critical reagent and process parameters.

- Deep understanding of reagent formulation principles and their influence on stability and functional performance; with practical experience across the full reagent development cycle including formulation, stability studies, and QC method development.

- Experience working with chemically reactive or environmentally sensitive compounds, including materials susceptible to degradation by oxygen, humidity, or light, with appropriate handling, storage, and stability assessment practices

- Strong experimental design skills, with the ability to plan and execute DOE-informed studies and interpret results against specifications.

- Experience developing reagents for multistep, integrated assay workflows involving multiple handoff points or checkpoints, including multi-omics or multi-component platforms.

- Experience establishing and maintaining robust SOPs for end-to-end integrated workflows, with consistent capture of key experimental variables, reagents, and process conditions — enabling cross-functional traceability and correlation with downstream data and performance.

- Excellent problem-solving skills and meticulous attention to detail.

- Strong written and verbal communication skills, with the ability to work effectively with colleagues across diverse scientific and technical backgrounds.

- Comfortable navigating a fast-paced, resource-constrained environment with shifting priorities.

Nice to have:

- Background in proteomics reagents, protein modification chemistry, peptide-oligonucleotide conjugates, or single-molecule assay components.

- Experience with automation platforms for liquid handling (e.g., Hamilton, ThermoFisher, Agilent) and protocol validation on automated workcells.

We're looking for a teammate that:

- Navigates complex team dynamics, partnerships, and challenges with creativity and logic.

- Operates with adaptability, urgency, and flexibility in evolving environments, thriving in ambiguity.

- Drives work forward without needing to be asked, taking responsibility for outcomes rather than tasks.

- Treats obstacles as problems to be creatively solved, not reasons something can't be done.

- Applies sound judgment to the best available information, testing, learning, and iterating.

- Shares early and directly when assumptions change, results are unclear, or timelines are at risk.

**What you can expect from this role**

Work environment:

- Collaborative culture where your ideas and expertise are valued

- Direct impact on product development and company direction

Professional growth:

- Learn from a diverse team of world-class scientists and engineers

- Contribute to first-of-their kind technologies, high-impact publications, and patents

**Compensation**

Estimated Base Salary $111,725 - $161,900

This is the pay range for this position that we reasonably expect to pay. Individual compensation is based on various factors including, experience, education, skillset, and geographic location. This range is for the SF Bay Area, California location and may be adjusted to the labor market in other geographic areas.

Benefits and Perks:

- Employee Stock Option Plan

- 100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)

- Employer Retirement Contributions to 401(k)

- Generous Paid Time Off

- Paid Maternity and Paternity Leave

- Health & Wellbeing Program

- Office Snacks and Beverages

- Regular Team Bonding Activities

We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Individuals seeking employment at Glyphic Biotechnologies are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.

Scientist / Senior Scientist, Assay Development (Reagents)

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