Industry: Biotechnology Research
Company Size: 2-10 employees

Damora Therapeutics

Savvy Admin PROD

**Senior Director, Supply Chain and Manufacturing Alliance Management **

**Hybrid - Boston Area **

**About Us **

Damora Therapeutics is an innovative biotechnology company that aims to fundamentally redefine care for people with hematologic disorders. We are advancing a new generation of biologics to treat mutant calreticulin-driven myeloproliferative neoplasms, including essential thrombocythemia and myelofibrosis, where there is significant medical need for new disease-modifying treatments. With multiple programs with best-in-class potential on track to enter clinical development in 2026, our goal is to rapidly bring forward optimized treatments with broad mutation coverage and exceptional convenience to dramatically improve patient outcomes.

This is a unique opportunity to join a science-driven company at a formative stage, where early clinical data will directly shape development strategy and drive long-term value. The right candidate will join a team with significant early- and late-stage development experience, with the goal of quickly moving through dose escalation/expansion into pivotal trials.

**The Role **

The **Senior Director, Supply Chain and Manufacturing Alliance Management **, will be responsible for overseeing and ensuring the seamless execution of supply chain operations and manufacturing collaborations for Damora. This role encompasses the strategic and operational leadership required for technical transfer, process validation, clinical supply management, and launch preparation. The incumbant will additionally act as the primary point of contact for financial forecasting, and contractual matters while supporting product lifecycle and regulatory readiness.

**What You'll Do **

Alliance Management:

- Serve as the single point of contact for all analytical, manufacturing, warehousing, and supply chain collaborations.

- Oversee execution of signed contracts, ensuring adherence to timelines, budgets, and resource allocation for all analytical, manufacturing, warehousing, and supply chain CDMOs.

- Provide 24-month manufacturing forecasts with monthly progress updates on collaborative activities.

- Address and escalate manufacturing or quality issues proactively driving resolution with our collaborations.

- Maintain a structured gap assessment to track changes in manufacturing processes and analytical testing for proactive management.

- Manage and maintain financial forecast for Technical Operations.

Supply Chain Leadership:

- Lead short- and mid-term forecasting of clinical demand and supply.

- Collaborate with Clinical Operations and external suppliers/CMOs to maintain adequate inventory levels and prevent supply disruptions.

- Implement or enhance tools to maintain up-to-date demand and supply tracking. Collaborates with Clinical Operations to maintain sufficient clinical supply.

- Monitor and coordinate release activities across supply chain stakeholders, including Drug Substance (DS), Drug Product (DP), labeling and packaging (L&P), and testing entities.

- Manages the inventory and shipment logistics of all Damora product and associated samples.

- Provides recommendations on packaging design and distribution. Plans and manages execution of initial supplies and resupplies for assigned studies. Designs and implements strategic plans to supply study drug to complex global clinical trials using sound supply chain techniques

- Acts as IRT System Lead, supports vendor selection activities, gathers and provides input into user requirement specifications of IRT management module(s)

- Reviews IRT strategy to ensure it supports the strategic supply plans and ensures that IRT is settings are adjusted to optimize the supply chain

- Leverages the inventory management capabilities of the IRT to appropriately manage studies

- Establish and lead ES&OP cycles to ensure launch readiness and standardize reporting for marketing and commercial teams.

**What You'll Bring **

- Bachelor's degree in science, engineering, or another relevant field; advanced degree preferred

- 15+ years of experience in supply chain and manufacturing within the biotech/pharma industry.

- Proven track record in alliance management and supply chain management.

- Experience in regulatory submissions, BLA preparation, and post-approval launch activities.

- Strong leadership capabilities in managing complex, multi-stakeholder environments.

- Ability to work in a fast-paced, high-stakes setting with cross-functional dependencies.

- Proven expertise in managing supply chain and manufacturing collaborations.

- Strong financial acumen for budgeting and forecasting.

- Exceptional problem-solving and conflict-resolution skills.

- Deep knowledge of technical transfer processes and regulatory submission requirements.

- Demonstrated leadership in cross-functional and global team environments.

- Excellent communication and relationship-building skills.

**Environment **

- Hybrid in the Boston area

- Dynamic, interactive, fast-paced, and entrepreneurial environment

- Domestic or international travel are required (10-20%)

**Compensation & Benefits **

At Damora Therapeutics, we offer competitive compensation and thoughtfully designed total rewards aligned with industry benchmarks. We believe in rewarding impact and building meaningful ownership for our team.

**Agency Policy **

We are building our team intentionally and do not accept unsolicited resumes from recruiting or staffing agencies. Agencies should not submit candidates unless directly engaged by Damora’s HR team and operating under a signed agreement. Any resume submitted without prior authorization and a signed agreement will be considered property of Damora Therapeutics, and no referral or placement fees will be paid.

Senior Director, Supply Chain and Manufacturing Alliance Management

**The Role **

We are seeking a Senior Director, Clinical Scientist to play a critical leadership role in the design, execution, analysis, and scientific oversight of our first-in-human clinical trials. This individual will serve as a senior scientific leader and key strategic partner to Clinical Development, Clinical Operations, Translational Science, Regulatory, Biometrics, and Safety, with significant responsibility for study-level strategy, scientific leadership, and cross-functional execution.

The Senior Director, Clinical Scientist will lead the development and authorship of key clinical and regulatory documents; drive ongoing clinical data review and interpretation; contribute to dose-escalation and development strategy decisions; and provide scientific leadership across internal governance and cross-functional forums. This individual will also help establish scalable clinical science processes and best practices as the organization grows.

This role reports to the Senior Vice President of Clinical Research Operations.

**What You’ll Do **

**Clinical Science Leadership & Trial Execution **

-  Serve as lead Clinical Scientist on one or more Phase 1 first-in-human dose escalation trials in hematologic malignancies.

- Contribute strategically to the clinical development plan for mCALR targeting antibodies, including study design, dose-escalation strategy, and data interpretation.

- Lead the development, authorship, and review of key clinical and cross-functional documents, including protocols, amendments, IBs, eCRFs, completion guidelines, SAP TLF shells, and regulatory briefing materials.

- Drive dose-escalation and study conduct discussions through real-time review and interpretation of emerging safety, PK/PD, biomarker, and clinical data.

- Provide scientific leadership and recommendations in data review meetings, SRCs, governance forums, and cross-functional team discussions.

**Cross-Functional Program Leadership **

- Serve as a core scientific leader across cross-functional program teams, partnering closely with Clinical Operations, Translational Medicine, Regulatory, Biometrics, and Safety.

- Drive alignment and execution across functions to support high-quality and timely study delivery.

- Collaborate with Translational and Preclinical teams to integrate biomarker and mechanistic hypotheses into clinical studies and broader development strategy.

- Proactively identify and address scientific, operational, and strategic risks and gaps.

**Data Review, Interpretation & Communication **

- Lead ongoing review and interpretation of clinical data, including safety, efficacy, PK/PD, and exploratory biomarkers.

- Develop clear scientific insights and recommendations to inform development strategy and clinical decision-making.

- Contribute to regulatory submissions, health authority responses, internal governance materials, and external scientific communications.

- Support preparation of abstracts, posters, manuscripts, and presentations for scientific meetings and publications.

**External & Operational Excellence **

- Provide scientific leadership in interactions with investigators, CROs, vendors, and external experts to support high-quality trial execution.

- Lead or support investigator meetings and scientific training sessions.

- Ensure strong organization, follow-through, and proactive management of deliverables across assigned studies and workstreams.

**What You Bring **

- PhD, PharmD, MD, or equivalent advanced scientific degree required.

- 8+ years of experience in clinical research or clinical development within the biotechnology or pharmaceutical industry.

- Deep understanding of clinical trial design, clinical data analysis, and drug development principles, with direct experience leading or supporting early-phase (Phase 1 / FIH) clinical trials.

- Strong scientific foundation in hematology or oncology required; MPN experience strongly preferred.

- Demonstrated ability to independently lead complex scientific workstreams and influence cross-functional teams in a fast-paced biotech environment.

- Proven experience leading development and authorship of clinical and regulatory documents.

- Strong analytical and scientific interpretation skills, including the ability to synthesize emerging clinical, safety, and biomarker data into actionable insights.

- Excellent written and verbal communication skills, with the ability to clearly communicate complex scientific concepts to diverse audiences.

Director/Sr. Director, Clinical Scientist

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