At Alumis, our goal is to significantly improve the lives of patients by replacing broad immunosuppression with targeted therapies.

We recognize that patients living with immune-mediated diseases need alternatives to currently available therapies. Despite recent advances and innovations in the treatment of immune-mediated diseases, many patients continue to suffer, cycling through currently approved therapies while looking for a solution that alleviates the debilitating impact of their disease without life-limiting side effects. 

Addressing the needs of these patients is why we exist. We are pioneering a precision approach that leverages insights we derive from powerful data analytics to select the right target, right molecule, right indication, right patient, and right endpoint resulting in optimized outcomes for patients. We believe that combining our insights with an integrated approach to drug development will produce the next generation of treatments to address immune dysfunction. 

Incubated by Foresite Labs, Alumis is led by a team of deeply experienced professionals who are devoted to transforming the lives of patients with immune-mediated diseases by developing a pipeline of transformative therapies.

Industry: Biotechnology Research
Company Size: 11-50 employees

Alumis

Savvy Admin PROD

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.

The small molecule CMC team is seeking highly motivated Sr. Scientist I of Analytical Development to help build our dynamic small molecule CMC group at Alumis. The successful candidate will help to support the analytical development and quality control activities from the preclinical phase through late-stage clinical development. Having analytical development expertise and experience in working with CMOs/CTLs, coupled with thorough understanding of the associated quality and regulatory awareness are key assets.

**RESPONSIBILITIES**

- Support development, validation, and transfer of analytical methods to support starting material, intermediate, drug substance and drug product testing at CMOs/CTLs

- Execute and/or support the in-house method development activities using UPLC/HPLC, LC-MS, KF, and dissolution instrumentation and techniques for Phase 1 to late-stage drug development

- Review CMO/CTL analytical data (in-process, release, and stability data), protocols and reports

- Trend stability and release data using statistical methods

- Assist in investigation for various non-conformance events at CMOs/CTLs

- Collaborate with CMC team, QA and CMOs/CTLs towards timely generation and approval of documents

- Communicate scientific results (oral and written) in a clear and concise manner within cross-functional teams

- Author technical reports and documents in support of regulatory filing

- Assist in preparation of CMC documents for regulatory submissions (IND, IMPD, and/or NDA)

**THE IDEAL CANDIDATE**

- BS/MS in chemistry or pharmaceutical sciences with 5+ years of experience in analytical development

- Experience with analytical techniques for small drug molecules and oral solid formulations required, including UPLC/HPLC, LC-MS, KF, dissolution testing, IR, particle size analysis, and solid-state characterization techniques

- Proven track record in applying analytical techniques to solve challenging problems

- Experience in working with CMOs and CTLs

- Experience in early to late-stage drug development

- Strong organizational and communication skills

- Comfortable in a fast-paced small company environment and a strong team player

- Experience and knowledge in ICH, cGMP and regulatory requirements

This position is located in South San Francisco, CA. At this time, we are not considering fully remote applicants.

~~The salary range for this position is $112,000 USD to $135,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices.~~

Alumis Inc. is an equal opportunity employer.

Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program.

Other benefits include:

- Health insurance premiums paid at 90% for employee, 80% for dependents

- Free access to Genentech Bus & Ferry Share program

- $100 monthly cell phone stipend

- Unlimited PTO for Exempt employees

- Free onsite gym and a kitchen stocked with yummy snacks and drinks!

We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to **elevate **, **challenge ** and **nurture ** one another along the way.

Senior Scientist I Analytical Development

BioSpace is the digital hub for life science news and jobs. We provide essential insights, opportunities and tools to connect innovative organizations and talented professionals who advance health and quality of life across the globe.

Industry: Internet News
Company Size: 11-50 employees

BioSpace

**The Role**

Moderna is seeking a Scientist to join the Analytical Development team in Norwood, MA. This individual will play a critical role in developing, optimizing, and implementing advanced analytical methods that support Moderna’s expanding therapeutic and vaccine portfolio. The successful candidate will generate high-quality data to drive method development, process understanding, and analytical readiness across new programs and manufacturing platforms.

The ideal candidate is hands-on, detail-oriented, and thrives in a collaborative, fast-paced environment. This role requires strong technical skills in chromatography, spectroscopy, and separation sciences, along with the ability to manage multiple projects and communicate effectively with cross-functional partners in Analytical Development, Process Development, and Quality.

**Here’s What You’ll Do**

- Develop and execute analytical methods, including mass spectrometry and HPLC with various detector configurations, to assess Moderna’s plasmid, mRNA, and LNP-based products.

- Perform intact mass analysis and primary structure characterization of proteins.

- Develop LC-MS/MS methods for qualitative and quantitative protein analysis.

- Generate feasibility data and support method development and optimization for novel platforms, including new plasmid manufacturing approaches and oncology programs.

- Collaborate cross-functionally with Research Analytics, Process Development, Quality Control, and Analytical Technical Operations to support method development, qualification, investigations, and technology transfer.

- Document experimental work in electronic lab notebooks and author technical reports, summaries, and method implementation documents.

- Maintain and troubleshoot LC-MS instrumentation, including Orbitrap, Q-TOF, and triple quadrupole systems.

- Maintain a strong focus on quality and data integrity, ensuring compliance with internal standards and regulatory expectations.

**Here’s What You’ll Need (Basic Qualifications)**

- PhD degree with 0-2 years or MS degree with 5+ years of relevant industry experience in Analytical Chemistry, Biochemistry, Chemistry, or related discipline.

- 4-5 years hands-on experience in LC-MS, HPLC, UV/Vis, spectroscopy, MAM workflows.

- Proficiency in software tools for MS data analysis (Xcalibur, MassHunter, Skyline, Biopharma Finder, Protein Metrics)

- Proven ability to perform method development, troubleshooting, and data analysis in support of biologics, RNA, or complex formulations.

- Familiarity with regulatory guidance, method transfer, and collaboration with Quality in a regulated environment is required.

- Familiarity with LNP characterization or nucleic acid-based analytical methods is a plus.

- Strong technical writing and documentation skills.

- Excellent organizational and multitasking ability in a fast-paced environment.

- Demonstrated collaboration and communication skills to work effectively with cross-functional teams.

- Highly motivated, scientifically curious, and capable of working independently with minimal supervision.

- This position is site-based, requiring you to be at Moderna’s site full-time. This position is not eligible for remote work.

**Pay & Benefits**

**At Moderna, we believe that when you feel your best, you can do your best work. That’s why our US benefits and global well-being resources are designed to support you—at work, at home, and everywhere in between.**

- Best-in-class healthcare coverage, plus voluntary benefit programs to support your unique needs

- A holistic approach to well-being, with access to fitness, mindfulness, and mental health support

- Family planning benefits, including fertility, adoption, and surrogacy support

- Generous paid time off, including vacation, volunteer days, sabbatical, global recharge days, and a discretionary year-end shutdown

- Savings and investment opportunities to help you plan for the future

- Location-specific perks and extras

The salary range for this role is $109,200.00 - $174,600.00. This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An individual’s position within the salary range will be based on several factors including, but not limited to, specific competencies, relevant education, qualifications, certifications, experience, skills, performance, and business or organizational needs. The successful candidate may be eligible for an annual discretionary bonus, other incentive compensation, or equity award, subject to company plan eligibility criteria and individual performance.

**About Moderna**

Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world.

By living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture. Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities.

We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S.

If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities.

**Our Working Model**

As we build our company, we have always believed an in-person culture is critical to our success. Moderna champions the significant benefits of in-office collaboration by embracing a 70/30 work model. This 70% in-office structure helps to foster a culture rich in innovation, teamwork, and direct mentorship. Join us in shaping a world where every interaction is an opportunity to learn, contribute, and make a meaningful impact.

Moderna is a smoke-free, alcohol-free, and drug-free work environment.

**Equal Opportunities**

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law.Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply!

Moderna is an E-Verify Employer in the United States. We consider qualified applicants regardless of criminal histories, consistent with legal requirements.

**Accommodations**

We’re focused on attracting, retaining, developing, and advancing our employees. By cultivating a workplace that values diverse experiences, backgrounds, and ideas, we create an environment where every employee can contribute their best.

Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should contact the Accommodations team at leavesandaccommodations@modernatx.com.

Export Control Notice This position may involve access to technology or data that is subject to U.S. export control laws, including the Export Administration Regulations (EAR). As such, employment is contingent upon the applicant’s ability to access export-controlled information in accordance with U.S. law. Due to the nature of the work and regulatory requirements, only individuals who qualify as U.S. persons (citizens, permanent residents, asylees, or refugees) are eligible for this position. For this role Moderna is unable to sponsor non-U.S. persons to apply for an export control license.

Scientist, Analytical Development

Wiley’s leading media brand providing first-hand information on the global chemical, life science and process industries

Industry: Zeitungsverlage
Company Size: 201–500 Beschäftigte

CHEManager International

Umoja Biopharma is an industry-leading biotech with locations in Seattle, WA and Louisville, CO, focused on transforming the treatment of cancer with a novel integrated immunotherapy platform. Our vision is to develop off-the-shelf therapies capable of treating any tumor, any time. We are a diverse and growing team working in brand-new facilities in downtown Seattle, Washington and Louisville, Colorado, and we are looking for innovative thinkers who are excited by groundbreaking science and technology, and passionate about squaring up to the challenges inherent to cutting-edge drug development. We are committed to our core values and principles that support our overall mission and strongly invite applications from enthusiastic individuals who share our commitment and help position Umoja to deliver on our goals. We at Umoja believe in the importance of stories; we are looking for great people to join our team to help us create more stories for ourselves, for you, and most importantly for patients and their families.

Umoja Biopharma - Your Body. Your Hope. Your Cure.

**Position Summary**

Umoja Biopharma is seeking a driven Scientist to understand and assess the potency of lentiviral drug products. This role will develop early- and late-stage potency methods for release of drug substance/product and generate data packages to support regulatory submissions. The position will work closely with other functions to deliver qualified/validated QC release and characterization assays, generate associated documentation, and oversee transfer of methods internally or externally to a CMO/CRO.

As a laboratory-based position within the technical operations organization, this position will play a critical role in advancing Umoja's pipeline and analytical development capabilities.

This role will be onsite 5 days/week based out of our Seattle, WA location.

**Core Accountabilities**

**Specific responsibilities include:**

- Successful design, execution, analysis, and documentation of experiments to develop analytical methods and key data packages for lentiviral gene therapies.

- Perform experiments to support analytical development and product characterization using advanced techniques including multicolor flow cytometry, ELISAs, Western blots, qPCR/dPCR, signal transduction and cytokine assays.

- Oversee the qualification of analytical methods.

- Author, review and approve technical documents including electronic notebook entries, standard operating procedures, test methods, technical reports, etc.

- Present findings on method development and communicate interpretation and strategic plans related to the potency of our drug product to cross-functional teams.

- Foster good teamwork and communication. Build a reputation of excellence as an individual and as a team.

- Collaborate with stakeholders within Analytical Development (Product Sciences and Process Analytics teams) and cross-functionally with Quality Control, CMC, Translational Medicine, Process Sciences, Discovery, and Vector Biology

- All other duties as assigned

**The Successful Candidate Will Have**

- PhD/MS/BS in Immunology, Cellular Biology, Molecular Biology or related discipline with at least 0+/8+/10+ years of experience, respectively; equivalent combination of education and experience will be considered

- Proven track record in cell-based method development, including troubleshooting assays, experimental design, execution, and evaluation of data

- Ability to work in a fast-paced environment with broad responsibilities, meet deadlines, and prioritize work on multiple projects

- Strong communication skills in technical writing and oral presentation. Respectful of others and open to new ideas.

**Preferred Qualifications**

- Hands-on experience with multicolor flow cytometry, cell-based assays, ELISAs, viral transduction, and qPCR/dPCR

- Experience qualifying and transferring analytical methods to a QC lab or CMO/CRO

- Experience developing and qualifying potency methods according to ICH/USP guidelines and authoring method documentation

**Physical Requirements**

- Ability to perform standard laboratory tasks with appropriate PPE

- Perform physical tasks required to support laboratory work, including standing, walking, bending, kneeling, sitting, working with your hands in a biosafety cabinet, and occasionally moving materials up to 50 pounds

- Ability to spend prolonged periods of time working on a computer

- Ability to work onsite 5 days/week

**Salary Range: $122,000 - $150,800**

**Benefits Offerings**

Umoja Biopharma offers its employees competitive Medical, Dental, and Vision plans. Additionally, we offer Umojians access to a 401k plan through Fidelity, with a 100% match up to their first 4% deferral. Umoja also provides a generous Paid Time Off policy, employee commuter benefits, and cell phone stipend. For a full breakdown of our benefits offerings, please see the **Benefits ** section of our website.

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