Seit mehr als 135 Jahren erforscht, entwickelt und produziert Boehringer Ingelheim neue Medikamente mit hohem therapeutischem Nutzen für Mensch und Tier. Als Pharmaunternehmen in Familienbesitz planen wir langfristig und investieren daher besonders in die Forschung und Entwicklung. Wir sind stolz, so einige der größten Gesundheitsprobleme unserer Zeit angehen zu können. Unsere Vision „Werte schaffen durch Innovation“ hat unsere Zusammenarbeit seit jeher geprägt und ist für uns Anspruch und Antrieb zugleich. Mit Hauptsitz in Ingelheim, Deutschland, beschäftigt Boehringer Ingelheim weltweit insgesamt rund 53.000 Mitarbeiter. Weitere Informationen zu Boehringer Ingelheim finden Sie unter www.boehringer-ingelheim.de

Industry: Arzneimittelherstellung
Company Size: 10.001+ Beschäftigte

Boehringer Ingelheim

Savvy Admin PROD

**Description**

The Department of Computational Innovation at Boehringer Ingelheim is seeking a highly motivated and accomplished Senior Principal Scientist to drive in silico evidence generation and advance novel therapeutic candidates (NTCs) through various milestones. This pivotal role will be instrumental in advancing our understanding of disease mechanisms and driving drug discovery efforts for new and underserved autoimmune disease indications. This role will leverage advanced computational approaches, particularly in bioinformatics, to elucidate NTC Mechanisms of Action (MoA) to facilitate late-stage project transitions in relevant patient segments.

The successful candidate will be a key contributor to our interdisciplinary team, collaborating closely with the Department of Immunology and Respiratory Disease Research (I&R), as well as in vitro and in vivo biologists. You will play a pivotal role in developing and applying cutting-edge omics-based approaches to accelerate drug discovery and development.

As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees

**Duties & Responsibilities**

-  In Silico Evidence Generation: Drive the generation of robust in silico evidence packages to support the progression of NTCs through critical development milestones.

-  Bioinformatics Project Leadership: Lead and execute bioinformatics projects to deliver innovative NTC MoA insights, with a particular emphasis on dermatological applications.

-  Advanced Computational Approaches: Leverage single and spatial omics technologies, machine learning/AI techniques, biological knowledge, and deep disease understanding to build compelling in silico evidence packages.

-  Clinical Biomarker & Safety/Toxicity Contribution: Contribute to clinical biomarker discovery efforts and/or data-driven safety and toxicity assessments.

-  Cross-Functional Collaboration: Work closely with colleagues in I&R, as well as in vitro and in vivo biologists, to integrate computational findings with experimental data.

-  Omics-Based Approach Development: Develop and implement novel omics-based computational approaches to address key challenges in drug development.

-  Drug Development Contribution: Apply computational expertise to various stages of the drug development pipeline, from target identification to late-stage clinical development.

**Requirements**

-  Ph.D. in Bioinformatics, Computational Biology, Immunology, Molecular Biology, or a related discipline with 7 or more years of relevant post-doctoral and/or industry experience in drug discovery and development, with at least three (3) years of experience in drug discovery.

-  Demonstrated expertise in understanding complex disease mechanisms, particularly within immunology, dermatology, and/or rheumatology.

-  Expertise in bioinformatics, including the analysis of large-scale biological datasets (e.g., single-cell RNA-seq, spatial transcriptomics, genomics, proteomics).

-  Proficiency in machine learning and artificial intelligence techniques for biological data analysis.

-  Strong understanding of immunology and disease mechanisms, particularly in the context of dermatology and rheumatology.

-  Experience collaborating with experimental biologists (in vitro and in vivo) to design experiments and interpret results.

-  Demonstrated ability to translate complex computational findings into clear and actionable insights for drug development teams.

-  Excellent communication, interpersonal, and presentation skills.

-  Proven ability to work independently and as part of a highly collaborative, multidisciplinary team.

-  Provides expert-level scientific and bioinformatics expertise within the area(s) of biology and human disease addressed by the TA.

-  Knowledge of current key datasets, therapeutic landscape and demographic/epidemiological considerations within TA is required.

Preferred Qualifications:

-  Experience with clinical biomarker discovery or data-driven safety & toxicity assessment.

-  Familiarity with regulatory requirements and guidelines in drug development.

-  Prior experience in dermatology and rheumatology research.

Eligibility Requirements:

-  Must be legally authorized to work in the United States without restriction.

-  Must be willing to take a drug test and post-offer physical (if required)

-  Must be 18 years of age or older

@computationalinnovation

**Compensation Data**

This position offers a base salary typically between $170,000.00 and $269,000.00 USD. The position may be eligible for a role specific variable or performance based bonus and or other compensation elements. For an overview of our benefits please click here .

Our Company

**Why Boehringer Ingelheim?**

With us, you can develop your own path in a company with a culture that knows our differences are our strengths - and break new ground in the drive to make millions of lives better.

Here, your development is our priority. Supporting you to build a career as part of a workplace that is independent, authentic and bold, while tackling challenging work in a respectful and friendly environment where everyone is valued and welcomed.

Alongside, you have access to programs and groups that ensure your health and wellbeing are looked after - as we make major investments to drive global accessibility to healthcare. By being part of a team that is constantly innovating, you'll be helping to transform lives for generations.

Want to learn more? Visit https://www.boehringer-ingelheim.com

Senior Principal Scientist, Portfolio In silico Evidence Lead, Computational Biology

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