At Merck, known as MSD outside of the United States and Canada, we are unified around our purpose: We use the power of leading-edge science to save and improve lives around the world. For more than 130 years, we have brought hope to humanity through the development of important medicines and vaccines. We aspire to be the premier research-intensive biopharmaceutical company in the world – and today, we are at the forefront of research to deliver innovative health solutions that advance the prevention and treatment of diseases in people and animals. We foster a diverse and inclusive global workforce and operate responsibly every day to enable a safe, sustainable and healthy future for all people and communities. For more information, visit www.merck.com. 

This site is intended for residents of the United States and Canada and their territories only. FLS: http://merck.us/3TKXNuZ

Industry: Pharmaceutical Manufacturing
Company Size: 10,001+ employees

Merck

Savvy Admin PROD

**Job Description**

The Materials and Biophysical Characterization group in Analytical Research and Development is seeking a highly self-motivated and innovative scientist with deep knowledge and strong problem-solving skills in biophysical characterization. The Biophysical Characterization team is responsible for building the mechanistic understanding of the interplay between formulation composition, process and stability of drug substance and drug product to ensure process robustness and product quality.

As a Senior Scientist, you will be supporting projects in the diverse pipeline by developing and implementing biophysical and particle characterization assays collaborating with process, formulation and device as part of the CMC development team. You are expected to use your scientific expertise to find creative solutions to challenging problems which require deep analytical insight and critical thinking. Additional responsibilities include authoring technical reports and regulatory documents, presenting technical data, and project management. You will conduct independent research, publish research findings, present at scientific conferences, and engage with various external scientific societies/organizations. This is an excellent growth and learning opportunity to work in an exciting, collaborative environment with a wide array of scientists from different divisions and make significant contributions towards our life-saving medicines.

**Education Minimum Requirement**

- Ph.D. in Biophysics, Biochemistry, Chemistry, Chemical Engineering, Biomedical Engineering, Pharmaceutical Sciences or related discipline with 0-4 years’ experience; OR

- MSc in Biophysics, Biochemistry, Chemistry, Chemical Engineering, Biomedical Engineering, Pharmaceutical Sciences or related discipline with 4-8 years’ experience.

**Required Experience And Skills**

- Fundamental understanding of protein science, protein stability, and protein-protein interactions

- Hands-on experience with biophysical and particle characterization techniques for biotherapeutics characterization, excellent analytical skills and the ability to analyze and interpret complex data sets

- Self-motivated with an outstanding scientific track-record; Track-record of independent problem-solving applying deep technical and subject matter expertise

- Excellent interpersonal and communication skills, actively engages in two-way communication to build trusting relationships.

- Excellent organizational skills to multi-task and manage multiple projects.

- Ability to drive operational excellence by clarifying and translating priorities into actionable steps, and ensure expectations are met aligned with agreed standards and methodologies

**Desired Experience And Skills**

- Experience with molecular modeling.

- Experience with cryoEM, BioNMR and/or Mass Spectrometry.

- Experience with biological formulation development and analytical method development.

- Experience with various modalities including peptides, mAbs, ADC, fusion proteins

#AR&D

**Required Skills**

Accountability, Adaptability, Bioprocessing, Cross-Functional Teamwork, Data Analysis, Drug Delivery Technology, Flow Cytometry, High-Throughput Screening, Innovative Thinking, Interpersonal Relationships, Molecular Biology Techniques, Multi-Color Flow Cytometry, Parasitology, Preformulation, Process Optimization, Protein Biochemistry, Protein Purifications, Scientific Research

**Preferred Skills**

Current Employees apply HERE

Current Contingent Workers apply HERE

**US And Puerto Rico Residents Only**

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

**Requirements**

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights

EEOC GINA Supplement

We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts

**U.S. Hybrid Work Model**

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

The salary range for this role is

$117,000.00 - $184,200.00

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

**San Francisco Residents Only: ** We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

**Los Angeles Residents Only: ** We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

**Search Firm Representatives Please Read Carefully**

Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

**Employee Status**

Regular

**Relocation:**

Domestic

**VISA Sponsorship**

No

**Travel Requirements**

10%

**Flexible Work Arrangements**

Not Applicable

**Shift**

Not Indicated

**Valid Driving License**

No

**Hazardous Material(s)**

N/A

**Job Posting End Date**

04/30/2026

- A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

**Requisition ID: **R387170

Sr. Scientist, Preclinical Dev.

**Job Description**

**Job Description:**

We seek a highly motivated and skilled chemist as a Senior Scientist to join our Labeled Compound Synthesis (LCS) group within the Discovery Process Chemistry organization located at our Rahway, NJ site. This role offers the opportunity to join a unique group of innovative laboratory scientists focused on synthesizing isotopically labeled compounds, essential to support drug discovery and development, and developing novel isotope labeling methodologies to enable and speed up and accelerate drug discovery and development. As a Senior Scientist, you will work on collaborative teams to design and synthesize stable and radioactive isotope-labeled drug candidates and metabolites using modern organic synthesis, analytical methods, and emerging technologies. We seek a motivated chemist who will become a subject-matter expert in isotopically labeled compound synthesis—including GMP synthesis for human ADME studies—and who demonstrates strong practical skills in complex molecule design, laboratory instrumentation, and problem solving. Creativity and adaptability are required to develop new labeling approaches, along with self‑initiative, attention to detail, and project planning skills. Excellent interpersonal ability to share specialist knowledge in multidisciplinary teams is essential. If you are passionate about synthetic organic chemistry and thrive in a dynamic environment, we encourage you to apply.

**Education Minimum Requirement**

- A Ph.D. in Chemistry, Pharmaceutical Sciences, or a closely related field achieved no later than June 2026.

Or

- M.S. in Chemistry, Pharmaceutical Sciences, or a closely related field with at least 3 years of industrial/ pharmaceutical experience.

Or

- B.S. in Chemistry, Pharmaceutical Sciences, or a closely related field with at least 5 years of industrial/pharmaceutical experience

**Qualifications**

- Extensive knowledge and experience with modern methods of organic synthetic chemistry.

- Skilled in analytical and purification techniques (including chromatography and crystallization)

- Good organizational, interpersonal, writing, and time management skills.

- Keen attention to detail and ability to author clear reports and review the reports of others.

- Ability to strictly follow established procedures, policies, and guidelines required to comply with safety/radiation safety, environmental, and GMP expectations in the lab.

- Demonstrated ability to develop, apply, and/or improve new workflows and best practices.

- Demonstrated ability to design and conduct experiments, generate and analyze data, properly dispose of waste, and work effectively in a dynamic environment.

**Preferred Experience And Skills**

- Experience working with stable and/or radioactive isotopes is desirable but not required.

- Experience with the synthesis of large molecules (peptides, RNAs, ADC-conjugates, etc.) is desirable but not required

- undefined.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

**Required Skills**

Accountability, Adaptability, Biopharmaceuticals, Chemical Synthesis, Chromatography, Data Analysis, Data-Driven Decision Making, Detail-Oriented, Emerging Technologies, GMP Compliance, Healthcare Innovation, Machine Learning (ML), Motivation Management, Organic Chemistry, Organic Synthesis, Time Management

**Preferred Skills**

Current Employees apply HERE

Current Contingent Workers apply HERE

**US And Puerto Rico Residents Only**

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

**Requirements**

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights

EEOC GINA Supplement

We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts

**U.S. Hybrid Work Model**

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

The salary range for this role is

$117,000.00 - $184,200.00

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

**San Francisco Residents Only: ** We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

**Los Angeles Residents Only: ** We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

**Search Firm Representatives Please Read Carefully**

Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

**Employee Status**

Regular

**Relocation:**

Domestic

**VISA Sponsorship**

Yes

**Travel Requirements**

No Travel Required

**Flexible Work Arrangements**

Not Applicable

**Shift**

1st - Day

**Valid Driving License**

No

**Hazardous Material(s)**

Yes

**Job Posting End Date**

04/25/2026

- A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

**Requisition ID: **R392202

Senior Scientist, Chemistry - Onsite

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