Monte Rosa Therapeutics is a clinical-stage biotechnology company developing highly selective molecular glue degrader (MGD) medicines for patients living with serious diseases in the areas of oncology, autoimmune and inflammatory diseases, and more. Monta Rosa’s QuEEN™ (Quantitative and Engineered Elimination of Neosubstrates) discovery engine combines AI-guided chemistry, diverse chemical libraries, structural biology and proteomics to identify degradable protein targets and rationally design MGDs with unprecedented selectivity. The QuEEN™ discovery engine enables access to a wide-ranging and differentiated target space of well-validated biology across multiple therapeutic areas. Monte Rosa has developed the industry’s leading pipeline of MGDs.

Industry: Biotechnology Research
Company Size: 51-200 employees

Monte Rosa Therapeutics

Savvy Admin PROD

Monte Rosa Therapeutics (MRT) seeks to recruit an experienced, creative and highly talented DMPK and ADME Scientist who is eager will assit in leading the discovery and development effort to grow the drug pipelines, as well as help lead external GxP compliance research efforts. The Scientist will work MRTx colleagues to participate in all stages of DMPK and ADME assessments, from initial compound screening through to IND and NDA regulatory submissions. Working with Research, Bioanalytical and Clinical Science subject matter experts, provides scientific expertise to ensure that clinical candidates with acceptable drug development characteristics are identified and appropriately characterized. Represents Preclinical Development on Research and Development teams and regularly interfaces with internal and external colleagues to ensure timely and accurate dissemination of DMPK and ADME findings

- Work closely with the medicinal chemistry team, the Scientist Position will lead the Nonclinical Development efforts in troubleshooting and guidance to the discovery project team with a particular focus on optimizing properties for oral administration

- Represent Nonclinical Development to project teams and present our work in the interpretation of ADME experimental data related to the in vitro and in vivo animal PK and biotransformation.

- Continually learn in vitro ADME and in vivo animal PK analysis (Winnolin)

- Coordinate outsourced in vitro and in vivo DMPK studies

- Explore new technologies and capabilities in discovery DMPK space

- Strong written and oral communication to support internal communication of data, study reports and regulatory documentation.

- Ability to work on multiple projects in a matrixed organizational structure

- Aide the Nonclinical Development & Clinical Pharmacology team’s activities across multiple project phases, including lead discovery, lead optimization, and regulatory filings.

- 7+ years of drug discovery industry experience in Drug Metabolism, Pharmacokinetics, Pharmaceutical Chemistry, Toxicology, or a related scientific discipline.

- Effective management of internal and external collaborations/service providers (CROs)

- Build relationships with peers and partners outside of Nonclinical Development & Clinical Pharmacology to enable high team performance.

- Demonstrates novel, innovative solutions to challenging problems using an extremely high degree of scientific discretion, intuition, and integrity.

- Strong collaboration and innovative skills across subject areas representing DMPK as a project team representative within the core team is a key requirement.

Experience in the design, conduct, and interpretation of in vitro and in vivo ADME and animal PK studies

Scientist,  ADME & BioAnalytical

BioSpace is the digital hub for life science news and jobs. We provide essential insights, opportunities and tools to connect innovative organizations and talented professionals who advance health and quality of life across the globe.

Industry: Internet News
Company Size: 11-50 employees

BioSpace

**Job Title **: Senior Principal Scientist, Lab Head Medicinal Chemistry

**Location: ** Cambridge, MA

Do you thrive on solving drug discovery challenges and driving therapeutic programs forward with speed and efficiency? Your skills could be critical in helping our teams accelerate progress.

Integrated Drug Discovery (IDD) is the small molecule drug discovery platform within Sanofi. IDD is an international, interdisciplinary group that spans medicinal chemistry, structural biology, screening, biochemistry, biophysics, cellular pharmacology, delivery technologies, sample management and more.

Our vision is to deliver valuable, high quality synthetic drugs of varying modalities to improve the lives of patients. Our mission is to provide innovation and key enabling technologies to drive the discovery of synthetic small molecules and emerging synthetic modalities as drug candidates in the Sanofi Research Portfolio; to deliver high quality science and innovative approaches to drug discovery, and to perform as a highly collaborative flexible and forward-looking organization with broad impact across the Sanofi pipeline. We are seeking a dynamic and experienced medicinal chemist to join our Cambridge, MA-based team as a Senior Principal Scientist.

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve peoples lives. Were also a company where you can flourish and grow your career, with many opportunities to explore, connect with people, and stretch the limits of what you thought was possible. Ready to get started?

**Main Responsibilities**

- The ideal candidate is an experienced leader who excels at solving complex challenges with innovative approaches, brings critical thinking and strategic vision, and consistently delivers results under pressure.

- A Senior Principal Scientist is responsible for applying deep scientific expertise and judgment to initiate, design, and direct medicinal chemistry in support of research goals.

- Is an expert in analyzing, interpreting and communicating scientific content to teams and stakeholders.

- Demonstrates continuous growth in depth and breadth of scientific knowledge and understanding of strategic goals of group, team and company.

- Successfully works as an impactful contributor, and as a leader of project teams and transverse initiatives; is an experienced and supportive manager and mentor of other medicinal chemists.

- Has an established and growing reputation in the external scientific community through high impact publications, productive scientific collaborations and active participation in conferences.

**Qualifications**

**About You**

- Demonstrated success leading multidisciplinary drug discovery projects from conception through key milestones.

- Experience in all phases of the small molecule discovery process from hit ID to candidate nomination.

- Exceptional technical skills and demonstrated ability to work and thrive in a collaborative cross-functional team setting; proven ability to analyze complex data sets, draw conclusions, and design follow-on experiments.

- Experience working with CROs and external collaborators.

- Comfortable and efficient in fast moving complex global environment.

- Demonstrated track record of intellectual contributions in drug discovery as evidenced by impactful peer-reviewed publications, presentations, patents, and project achievements.

- Proven track record mentoring and developing junior scientists with measurable impact on team performance and individual career growth.

- PhD in Organic/Medicinal Chemistry with 7+ years of experience in a pharmaceutical/biopharmaceutical environment.

- Or Masters degree in Organic Chemistry with 9+ years of experience in a pharmaceutical/biopharmaceutical environment.

- Or Bachelors degree with 12+ years of experience in a pharmaceutical/biopharmaceutical environment.

**Why Choose Us?**

- Bring the miracles of science to life alongside a supportive, future-focused team.

- Discover endless opportunities to grow your talent and drive your career, whether its through a promotion or lateral move, at home or internationally.

- Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

- Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks gender-neutral parental leave.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

#GD-SA

#vhd

All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.

Senior Principal Scientist, Lab Head Medicinal Chemistry

Powered by Labelbox. Earn money by teaching AI models. Get paid to align groundbreaking AI models with your expertise

Industry: Technology, Information and Internet
Company Size: 11-50 employees

Alignerr

**Chemistry Subject Matter Expert (AI Training)**

**About The Role**

We're looking for chemistry experts to help train and improve the next generation of AI models. Your deep scientific knowledge will directly shape how AI understands and reasons through complex chemistry problems — from undergraduate fundamentals to advanced graduate-level topics.

This is a rare opportunity to work at the intersection of science and cutting-edge AI, collaborating with leading research labs without leaving your home.

- Organization: Alignerr

- Type: Hourly Contract

- Location: Remote

- Commitment: 10–40 hours/week

**What You'll Do**

- Design rigorous, advanced chemistry problems to test and challenge AI performance across domains such as organic chemistry, biochemistry, and chemical engineering

- Develop clear, step-by-step solutions with structured reasoning and scientific accuracy

- Evaluate AI-generated outputs for correctness, logical soundness, and quality of reasoning

- Collaborate with researchers to build and refine benchmarks spanning undergraduate through Master's-level chemistry

- Provide detailed, constructive feedback that directly improves AI model performance

**Who You Are**

- Currently pursuing or have completed a Master's degree in Chemistry, Chemical Engineering, Biochemistry, or a closely related field

- Strong analytical and problem-solving skills across advanced chemistry domains

- Able to communicate complex scientific concepts clearly and precisely in writing

- Self-motivated and comfortable working independently on a flexible schedule

- No prior AI experience required — your chemistry expertise is what matters

**Nice to Have**

- Experience with data annotation, data quality assessment, or evaluation systems

- Familiarity with AI or machine learning concepts

- Background in research, academic writing, or technical content creation

**Why Join Us**

- Work on cutting-edge AI projects with world-leading research labs

- Fully remote and flexible — work on your own schedule, from anywhere

- Freelance perks: high autonomy, variety, and global collaboration

- Make a meaningful contribution to how AI understands science

- Potential for ongoing work and contract extension

Chemistry Subject Matter Expert - AI Content Specialist

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